Review articles

Current progress and limitations of spider silk for biomedical applications
Widhe, M., Johansson, J., Hedhammar, M., Rising, A (2012) Biopolymers, 97 (6), pp. 468-478

Spider silk proteins: Recent advances in recombinant production, structure-function relationships and biomedical applications
Rising, A., Widhe, M., Johansson, J., Hedhammar, M.
(2011) Cellular and Molecular Life Sciences, 68 (2), pp. 169-184



Peer-reviewed original articles


Efficient protein production inspired by how spiders make silk
Kronqvist, N, et al.
(2017) Nature communications 8:15504

Ultrastrong and Bioactive Nanostructured Bio-Based Composites
Mittal, N, et al.
(2017) CS Nano, 11 (5), pp 5148–5159

Self-assembly of recombinant silk as a strategy for chemical-free formation of bioactive coatings: a real-time study
Nilebäck, L., Hedin, J., Widhe, M., Floderus, L., Krona, A., Bysell, H., Hedhammar, M.
(2017) BioMacromolecules, 18(3), pp. 846-854


Silk matrices promote formation of insulin-secreting islet-like clusters
Shalaly, N.D., Ria, M., Johansson, U., Åvall, K., Berggren, P.-O., Hedhammar, M.
(2016) Biomaterials, 90, pp. 50-61

Efficient passage of human pluripotent stem cells on spider silk matrices under xeno-free conditions
Wu, S., Johansson, J., Hovatta, O., Rising, A.
(2016) Cellular and Molecular Life Sciences, 73 (7), pp. 1479-1488

Functionalized silk assembled from a recombinant spider silk fusion protein (Z-4RepCT) produced in the methylotrophic yeast Pichia pastoris
Jansson, R., Lau, C.H., Ishida, T., Ramström, M., Sandgren, M., Hedhammar, M.
(2016) Biotechnology Journal, 11 (5), pp. 687-699

Genetic fusion of single-chain variable fragments to partial spider silk improves target detection in micro- and nanoarrays
Thatikonda, N., Delfani, P., Jansson, R., Petersson, L., Lindberg, D., Wingren, C., Hedhammar, M.
(2016) Biotechnology Journal, 11 (3), pp. 437-448

A fibronectin mimetic motif improves integrin mediated cell biding to recombinant spider silk matrices
Widhe, M., Shalaly, N.D., Hedhammar, M.
(2016) Biomaterials, 74, pp. 256-266


Pancreatic islet survival and engraftment is promoted by culture on functionalized spider silk matrices
Johansson, U., Ria, M., Åvall, K., Shalaly, N.D., Zaitsev, S.V., Berggren, P.-O., Hedhammar, M.
(2015) PLoS ONE, 10 (6)

Rational Design of Spider Silk Materials Genetically Fused with an Enzyme
Jansson, R., Courtin, C.M., Sandgren, M., Hedhammar, M.(2015) Advanced Functional Materials, 25 (33), pp. 5343-5352


Recombinant spider silk genetically functionalized with affinity domains
Jansson, R., Thatikonda, N., Lindberg, D., Rising, A., Johansson, J., Nygren, P.-A., Hedhammar, M.
(2014) Biomacromolecules, 15 (5), pp. 1696-1706

Spider silk for xeno-free long-term self-renewal and differentiation of human pluripotent stem cells
Wu, S., Johansson, J., Damdimopoulou, P., Shahsavani, M., Falk, A., Hovatta, O., Rising, A.
(2014) Biomaterials, 35 (30), pp. 8496-8502


Recombinant spider silk with cell binding motifs for specific adherence of cells
Widhe, M., Johansson, U., Hillerdahl, C.-O., Hedhammar, M.
(2013) Biomaterials, 34 (33), pp. 8223-8234


pH-dependent dimerization of spider silk N-terminal domain requires relocation of a wedged tryptophan side chain
Jaudzems, K., Askarieh, G., Landreh, M., Nordling, K., Hedhammar, M., Jörnvall, H., Rising, A., Knight, S.D., Johansson, J.
(2012) Journal of Molecular Biology, 422 (4), pp. 477-487

Recombinant spider silk matrices for neural stem cell cultures
Lewicka, M., Hermanson, O., Rising, A.U.
(2012) Biomaterials, 33 (31), pp. 7712-7717


Functionalisation of recombinant spider silk with conjugated polyelectrolytes
Müller, C., Jansson, R., Elfwing, A., Askarieh, G., Karlsson, R., Hamedi, M., Rising, A., Johansson, J., Inganäs, O., Hedhammar, M.
(2011) Journal of Materials Chemistry, 21 (9), pp. 2909-2915


Recombinant spider silk as matrices for cell culture
Widhe, M., Bysell, H., Nystedt, S., Schenning, I., Malmsten, M., Johansson, J., Rising, A., Hedhammar, M.
(2010) Biomaterials, 31 (36), pp. 9575-9585

Self-assembly of spider silk proteins is controlled by a pH-sensitive relay
Askarieh, G., Hedhammar, M., Nordling, K., Saenz, A., Casals, C., Rising, A., Johansson, J., Knight, S.D.
(2010) Nature, 465 (7295), pp. 236-238

Sterilized recombinant spider silk fibers of low pyrogenicity
Hedhammar, M.Y., Bramfeldt, H., Baris, T., Widhe, M., Askarieh, G., Nordling, K., Aulock, S.V., Johansson, J.
(2010) Biomacromolecules, 11 (4), pp. 953-959

A pH-Dependent Dimer Lock in Spider Silk Protein
Landreh, M., Askarieh, G., Nordling, K., Hedhammar, M., Rising, A., Casals, C., Astorga-Wells, J., Alvelius, G., Knight, S.D., Johansson, J., Jörnvall, H., Bergman, T.
(2010) Journal of Molecular Biology, 404 (2), pp. 328-336


Tissue response to subcutaneously implanted recombinant spider silk: An in vivo study
Fredriksson, C., Hedhammar, M., Feinstein, R., Nordling, K., Kratz, G., Johansson, J., Huss, F., Rising, A.
(2009) Materials, 2 (4), pp. 1908-1922

Engineered disulfides improve mechanical properties of recombinant spider silk
Grip, S., Johansson, J., Hedhammar, M.
(2009) Protein science : a publication of the Protein Society, 18 (5), pp. 1012-1022


Structural properties of recombinant nonrepetitive and repetitive parts of major ampullate spidroin 1 from Euprosthenops australis: Implications for fiber formation
Hedhammar, M., Rising, A., Grip, S., Martinez, A.S., Nordling, K., Casals, C., Stark, M., Johansson, J.
(2008) Biochemistry, 47 (11), pp. 3407-3417


Macroscopic fibers self-assembled from recombinant miniature spider silk proteins
Stark, M., Grip, S., Rising, A., Hedhammar, M., Engström, W., Hjälm, G., Johansson, J.
(2007) Biomacromolecules, 8 (5), pp. 1695-1701

Major ampullate spidroins from Euprosthenops australis: Multiplicity at protein, mRNA and gene levels
Rising, A., Johansson, J., Larson, G., Bongcam-Rudloff, E., Engström, W., Hjälm, G.
(2007) Insect Molecular Biology, 16 (5), pp. 551-561


N-terminal nonrepetitive domain common to dragline, flagelliform, and cylindriform spider silk proteins
Rising, A., Hjälm, G., Engström, W., Johansson, J.
(2006) Biomacromolecules, 7 (11), pp. 3120-3124