Publications


Review articles

Current progress and limitations of spider silk for biomedical applications
Widhe, M., Johansson, J., Hedhammar, M., Rising, A (2012) Biopolymers, 97 (6), pp. 468-478
https://doi.org/10.1002/bip.21715

Spider silk proteins: Recent advances in recombinant production, structure-function relationships and biomedical applications
Rising, A., Widhe, M., Johansson, J., Hedhammar, M.
(2011) Cellular and Molecular Life Sciences, 68 (2), pp. 169-184
https://doi.org/10.1007/s00018-010-0462-z

 

 

Peer-reviewed original articles

2016

Silk matrices promote formation of insulin-secreting islet-like clusters
Shalaly, N.D., Ria, M., Johansson, U., Åvall, K., Berggren, P.-O., Hedhammar, M.
(2016) Biomaterials, 90, pp. 50-61
https://doi.org/10.1016/j.biomaterials.2016.03.006

Efficient passage of human pluripotent stem cells on spider silk matrices under xeno-free conditions
Wu, S., Johansson, J., Hovatta, O., Rising, A.
(2016) Cellular and Molecular Life Sciences, 73 (7), pp. 1479-1488
https://doi.org/10.1007/s00018-015-2053-5

Functionalized silk assembled from a recombinant spider silk fusion protein (Z-4RepCT) produced in the methylotrophic yeast Pichia pastoris
Jansson, R., Lau, C.H., Ishida, T., Ramström, M., Sandgren, M., Hedhammar, M.
(2016) Biotechnology Journal, 11 (5), pp. 687-699
https://doi.org/10.1002/biot.201500412

Genetic fusion of single-chain variable fragments to partial spider silk improves target detection in micro- and nanoarrays
Thatikonda, N., Delfani, P., Jansson, R., Petersson, L., Lindberg, D., Wingren, C., Hedhammar, M.
(2016) Biotechnology Journal, 11 (3), pp. 437-448
https://doi.org/10.1002/biot.201500297

A fibronectin mimetic motif improves integrin mediated cell biding to recombinant spider silk matrices
Widhe, M., Shalaly, N.D., Hedhammar, M.
(2016) Biomaterials, 74, pp. 256-266
https://doi.org/10.1016/j.biomaterials.2015.10.013

2015

Pancreatic islet survival and engraftment is promoted by culture on functionalized spider silk matrices
Johansson, U., Ria, M., Åvall, K., Shalaly, N.D., Zaitsev, S.V., Berggren, P.-O., Hedhammar, M.
(2015) PLoS ONE, 10 (6)
https://doi.org/10.1371/journal.pone.0130169

Rational Design of Spider Silk Materials Genetically Fused with an Enzyme
Jansson, R., Courtin, C.M., Sandgren, M., Hedhammar, M.(2015) Advanced Functional Materials, 25 (33), pp. 5343-5352
https://doi.org/10.1002/adfm.201501833

2014

Recombinant spider silk genetically functionalized with affinity domains
Jansson, R., Thatikonda, N., Lindberg, D., Rising, A., Johansson, J., Nygren, P.-A., Hedhammar, M.
(2014) Biomacromolecules, 15 (5), pp. 1696-1706
https://doi.org/10.1021/bm500114e

Spider silk for xeno-free long-term self-renewal and differentiation of human pluripotent stem cells
Wu, S., Johansson, J., Damdimopoulou, P., Shahsavani, M., Falk, A., Hovatta, O., Rising, A.
(2014) Biomaterials, 35 (30), pp. 8496-8502
https://doi.org/10.1016/j.biomaterials.2014.06.039

2013

Recombinant spider silk with cell binding motifs for specific adherence of cells
Widhe, M., Johansson, U., Hillerdahl, C.-O., Hedhammar, M.
(2013) Biomaterials, 34 (33), pp. 8223-8234
https://doi.org/10.1016/j.biomaterials.2013.07.058

2012

pH-dependent dimerization of spider silk N-terminal domain requires relocation of a wedged tryptophan side chain
Jaudzems, K., Askarieh, G., Landreh, M., Nordling, K., Hedhammar, M., Jörnvall, H., Rising, A., Knight, S.D., Johansson, J.
(2012) Journal of Molecular Biology, 422 (4), pp. 477-487
https://doi.org/10.1016/j.jmb.2012.06.004

Recombinant spider silk matrices for neural stem cell cultures
Lewicka, M., Hermanson, O., Rising, A.U.
(2012) Biomaterials, 33 (31), pp. 7712-7717
https://doi.org/10.1016/j.biomaterials.2012.07.021

2011

Functionalisation of recombinant spider silk with conjugated polyelectrolytes
Müller, C., Jansson, R., Elfwing, A., Askarieh, G., Karlsson, R., Hamedi, M., Rising, A., Johansson, J., Inganäs, O., Hedhammar, M.
(2011) Journal of Materials Chemistry, 21 (9), pp. 2909-2915
https://doi.org/10.1039/c0jm03270k

2010

Recombinant spider silk as matrices for cell culture
Widhe, M., Bysell, H., Nystedt, S., Schenning, I., Malmsten, M., Johansson, J., Rising, A., Hedhammar, M.
(2010) Biomaterials, 31 (36), pp. 9575-9585
https://doi.org/10.1016/j.biomaterials.2010.08.061

Self-assembly of spider silk proteins is controlled by a pH-sensitive relay
Askarieh, G., Hedhammar, M., Nordling, K., Saenz, A., Casals, C., Rising, A., Johansson, J., Knight, S.D.
(2010) Nature, 465 (7295), pp. 236-238
https://doi.org/10.1038/nature08962

Sterilized recombinant spider silk fibers of low pyrogenicity
Hedhammar, M.Y., Bramfeldt, H., Baris, T., Widhe, M., Askarieh, G., Nordling, K., Aulock, S.V., Johansson, J.
(2010) Biomacromolecules, 11 (4), pp. 953-959
https://doi.org/10.1021/bm9014039

A pH-Dependent Dimer Lock in Spider Silk Protein
Landreh, M., Askarieh, G., Nordling, K., Hedhammar, M., Rising, A., Casals, C., Astorga-Wells, J., Alvelius, G., Knight, S.D., Johansson, J., Jörnvall, H., Bergman, T.
(2010) Journal of Molecular Biology, 404 (2), pp. 328-336
https://doi.org/10.1016/j.jmb.2010.09.054

2009

Tissue response to subcutaneously implanted recombinant spider silk: An in vivo study
Fredriksson, C., Hedhammar, M., Feinstein, R., Nordling, K., Kratz, G., Johansson, J., Huss, F., Rising, A.
(2009) Materials, 2 (4), pp. 1908-1922
https://doi.org/10.3390/ma2041908

Engineered disulfides improve mechanical properties of recombinant spider silk
Grip, S., Johansson, J., Hedhammar, M.
(2009) Protein science : a publication of the Protein Society, 18 (5), pp. 1012-1022
https://doi.org/10.1002/pro.111

2008

Structural properties of recombinant nonrepetitive and repetitive parts of major ampullate spidroin 1 from Euprosthenops australis: Implications for fiber formation
Hedhammar, M., Rising, A., Grip, S., Martinez, A.S., Nordling, K., Casals, C., Stark, M., Johansson, J.
(2008) Biochemistry, 47 (11), pp. 3407-3417
https://doi.org/10.1021/bi702432y

2007

Macroscopic fibers self-assembled from recombinant miniature spider silk proteins
Stark, M., Grip, S., Rising, A., Hedhammar, M., Engström, W., Hjälm, G., Johansson, J.
(2007) Biomacromolecules, 8 (5), pp. 1695-1701
https://doi.org/10.1021/bm070049y

Major ampullate spidroins from Euprosthenops australis: Multiplicity at protein, mRNA and gene levels
Rising, A., Johansson, J., Larson, G., Bongcam-Rudloff, E., Engström, W., Hjälm, G.
(2007) Insect Molecular Biology, 16 (5), pp. 551-561
https://doi.org/10.1111/j.1365-2583.2007.00749.x

2006

N-terminal nonrepetitive domain common to dragline, flagelliform, and cylindriform spider silk proteins
Rising, A., Hjälm, G., Engström, W., Johansson, J.
(2006) Biomacromolecules, 7 (11), pp. 3120-3124
https://doi.org/10.1021/bm060693x